Abstract #0980

Probing complex morphologies at decreasing diffusion times using Diffusion-weighted MR Spectroscopy

Nathalie Just¹, Samo Lasič^2,3, Ditte Bentsen Christensen⁴, Julien Valette⁵, Tim Dyrby^2,6, Hartwig Siebner², and Henrik Lundell²

¹Danish Research Center for Magnetic Resonance, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark, ²Danish Research Center for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark, ³Random Walk Imaging, Lund, Sweden, ⁴HYPERMAG, DTU, Copenhagen, Denmark, ⁵MIRCen, Commissariat à l' energie atomique et aux Energies Alternatives, Fontenay-aux-Roses, France, ⁶Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark

Synopsis

Metabolite diffusion provide the unique ability to study the intracellular environment of specific cell types of the brain. Multiple studies suggest that the diffusivity along dendrites and axons is time dependent due to variations in diameter. We explore the signal due to such effects in Monte Carlo simulations in settings feasible for preclinical PGSE measurements and find that time dependent kurtosis, but not diffusivity provide the most potent source of contrast to this effect. We observe similar effects of intraneuronal NAA diffusion in rat.

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