Meeting Banner
Abstract #0981

How to understand diffusion MRI changes in the white matter of Multiple Sclerosis patients?

Ying Liao1, Santiago Coelho1, Wafaa Sweidan1, Jenny Chen1, Dmitry S. Novikov1, and Els Fieremans1
1Radiology, NYU School of Medicine, New York, NY, United States


Conventional diffusion MRI (dMRI) techniques, such as DTI and DKI, are sensitive to pathology but lack specificity. In brain white matter, the “Standard Model” framework of dMRI may provide specificity to microstructural changes. Generally, clinical dMRI is noisy and limited, making SM estimation challenging. Thus, different constraints and techniques have been introduced to robustly extract SM parametric maps. Here, we employ a large clinical dataset of Multiple Sclerosis patient data (N = 134) and noise propagation experiments to study the sensitivity and specificity of these techniques.

This abstract and the presentation materials are available to members only; a login is required.

Join Here