Abstract #0984

Diffusion dispersion and microscopic fractional anisotropy reveal acute sensitivity to mild traumatic brain injury in a mouse model

Naila Rahman^1,2, Kathy Xu², Arthur Brown^2,3, and Corey Baron^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Anatomy and Cell Biology, Western University, London, ON, Canada

Synopsis

Imaging markers of mild to moderate concussion are notoriously difficult to detect in vivo. Advanced diffusion MRI (dMRI) techniques have shown increased sensitivity and specificity to microstructural changes in various disease and injury models. Oscillating gradient spin-echo (OGSE) dMRI is sensitive to structural disorder and microscopic anisotropy (µA) dMRI is sensitive to water diffusion anisotropy independent of neuron fiber orientation. In this work, we demonstrate that both microscopic fractional anisotropy and diffusion dispersion show acute sensitivity to concussion, while traditional diffusion MRI markers do not.

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