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Abstract #0987

VERDICT MRI for estimation of intracellular volume fraction and cell radius: comparison with histology in a mouse model of neuroendocrine tumor

Lukas Lundholm1, Mikael Montelius1, Oscar Jalnefjord1,2, Eva Forssell-Aronsson1,2, and Maria Ljungberg1,2
1Medical Radiation Sciences, University of Gothenburg, Gothenburg, Sweden, 2Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden


VERDICT MRI provides estimates of intracellular volume fraction and cell radius non-invasively which may facilitate e.g., tumor grade classification and longitudinal studies without the need for biopsy. Tumors of a human SI-NET animal model were irradiated and measured with diffusion MRI. Colormaps of cell radius index and intracellular fraction were derived from both VERDICT analysis of the MR data and histological analysis of stained tumor slices. VERDICT maps of intracellular fraction corresponded well with histology in necrotic tissue, however the cell radius index was poorly estimated in these regions. Further work is needed to optimize VERDICT for different tissue types.

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