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Abstract #0999

Temporal resolution impacts in-vivo human brain dynamic functional MRI connectivity

Francesca Saviola1, Stefano Tambalo1, Dimitri Van De Ville2,3, and Jorge Jovicich1
1University of Trento, Center for Mind/Brain Sciences, Rovereto, Italy, 2Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland


The advent of fast fMRI acquisition techniques has enabled whole-brain acquisitions with sub-second temporal resolution enriching the information available throughout the time course. However, there is no consensus about how the application of frame-wise analysis, performed to better understand functional brain fluctuations, could benefit from high temporal resolution fMRI. In this work, we demonstrate the potential need to: (i) gain a finer understanding of signal and noise signatures peculiar to fast acquisition and (ii) extend the models to better estimate dynamic functional connectivity in rapidly sampled fMRI time series.

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