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Abstract #1000

First evidence of a link between topology and neurophysiological properties of brain sub-networks.

Anita Monteverdi1,2, Fulvia Palesi2, Claudia AM Gandini Wheeler-Kingshott1,2,3, and Egidio D'Angelo1,2
1Brain Connectivity Center, IRCCS Mondino Foundation, Pavia, Italy, 2Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 3NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom


A comprehensive assessment of multiple resting-state networks is still lacking and the characterization of their excitatory/inhibitory (E/I) balance is an open field of research. In this exploratory work we performed a first characterization of the E/I balance in resting-state networks (visual, somatomotor, attention, limbic, frontoparietal, DMN) both in healthy and neurodegenerative conditions (Alzheimer’s Disease, Frontotemporal Dementia, Amyotrophic Lateral Sclerosis) taking advantage of a Virtual Brain based approach. Our results provided a new strategy to simultaneously characterize multiple networks at single-subject level, deepening their E/I balance and opening new perspectives for biomarkers research.

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