A New MRI acquisition method for quantitative myocardial oxygen extraction imaging
Jie Zheng1,2, Ran Li1,2, Cihat Eldeniz1, Thomas H Schindler1, Linda R Peterson3, and Pamela K Woodard1,2
1Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, MO, United States, 2Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, United States, 3Department of Medicine, Cardiovascular Division, Washington University in St. Louis, Saint Louis, MO, United States
A previously developed MRI method for quantitative myocardial oxygen extraction mapping showed promising results, but image quality suffered from distortion and low in-plane resolution. Therefore we developed a new image acquisition method which both doubled the in-plane spatial resolution and corrected image distortion and tested it in healthy subjects. Reproducibility studies showed comparable results between the two methods. Rigorous animal and/or human validation studies are warranted to study its translational potential in the assessment of patients with myocardial metabolic dysfunction.
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