Abstract #1006

A New MRI acquisition method for quantitative myocardial oxygen extraction imaging

Jie Zheng^1,2, Ran Li^1,2, Cihat Eldeniz¹, Thomas H Schindler¹, Linda R Peterson³, and Pamela K Woodard^1,2

¹Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, MO, United States, ²Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, United States, ³Department of Medicine, Cardiovascular Division, Washington University in St. Louis, Saint Louis, MO, United States

Synopsis

A previously developed MRI method for quantitative myocardial oxygen extraction mapping showed promising results, but image quality suffered from distortion and low in-plane resolution. Therefore we developed a new image acquisition method which both doubled the in-plane spatial resolution and corrected image distortion and tested it in healthy subjects. Reproducibility studies showed comparable results between the two methods. Rigorous animal and/or human validation studies are warranted to study its translational potential in the assessment of patients with myocardial metabolic dysfunction.

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