Abstract #1007

MR chemical exchange saturation transfer study of myocardium creatine dynamic change in an acute infarct porcine model

Chuan-Miao Xie¹, Jie Liu², Jia-Lei Zhao², Qi Liu³, Jian Xu³, Li-Yun Zheng⁴, Xin Liu², Hairong Zheng², and Yin Wu²

¹Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, ²Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ³UIH America, Inc., Houston, TX, United States, ⁴Central Research Institute, United Imaging Healthcare, Shanghai, China

Synopsis

This study investigated the dynamic alteration of myocardium creatine in infarct hearts using CEST MRI. Seven pigs underwent cine, Cr CEST and LGE imaging 3 and 14 days after MI. Significant increase of stroke volume and ejection fraction and decrease of infarct angle were observed at day 14 compared to that at day 3. Meanwhile, Cr CEST signals increased significantly in the infarct and its adjacent myocardium, and negatively correlated with infarct angle. The improved metabolic activity was associated with function recovery, indicating that Cr CEST MRI is promising to provide complementary information for heart remodeling at the molecular level.

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