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Abstract #1007

MR chemical exchange saturation transfer study of myocardium creatine dynamic change in an acute infarct porcine model

Chuan-Miao Xie1, Jie Liu2, Jia-Lei Zhao2, Qi Liu3, Jian Xu3, Li-Yun Zheng4, Xin Liu2, Hairong Zheng2, and Yin Wu2
1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China, 2Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3UIH America, Inc., Houston, TX, United States, 4Central Research Institute, United Imaging Healthcare, Shanghai, China


This study investigated the dynamic alteration of myocardium creatine in infarct hearts using CEST MRI. Seven pigs underwent cine, Cr CEST and LGE imaging 3 and 14 days after MI. Significant increase of stroke volume and ejection fraction and decrease of infarct angle were observed at day 14 compared to that at day 3. Meanwhile, Cr CEST signals increased significantly in the infarct and its adjacent myocardium, and negatively correlated with infarct angle. The improved metabolic activity was associated with function recovery, indicating that Cr CEST MRI is promising to provide complementary information for heart remodeling at the molecular level.

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