Abstract #1009

Dynamic UTE molecular MR imaging targeting pulmonary fibrogenesis in a model of left ventricular dysfunction

Brianna F. Moon^1,2, Iris Y. Zhou^1,2, Yingying Ning^1,2, Sergey Shuvaev^1,2, Mariane M. Le Fur^1,2, Yin-Ching I. Chen¹, Eman A. Akam³, Jonah P. Weigand-Whittier¹, Nicholas Rotile^1,2, Matthew Drummond⁴, Avery T. Boice^1,2, Samantha E. Zygmont^1,2, Rod R. Warburton⁵, Barry L. Fanburg⁵, Krishna C. Penumatsa⁵, and Peter D. Caravan^1,2

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Radiology, Institute for Innovation in Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Medicine, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ⁴Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ⁵Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, MA, United States

Synopsis

Group 2 pulmonary hypertension is a complication of chronic left ventricular dysfunction. During the early stages of the disease activity there is an accumulation of extracellular matrix molecules and an increase in allysine content. Molecular MR imaging with an allysine-targeted fibrogenesis probe shows increased lung-to-muscle ΔCNR within the lungs of transverse aortic constriction (TAC)-induced left ventricular dysfunction animal models compared to control animals, which corresponded to increased lung and right ventricle weight, and elevation of fibrogenesis biomarkers (hydroxyproline and allysine).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.