Three-dimensional first-pass myocardial perfusion CMR requires acceleration methods to enable whole-heart coverage in a limited acquisition window. Current 3D approaches suffer from data inconsistencies during free breathing, compromising image quality and perfusion quantification. We propose and experimentally validate a combination of Cartesian pseudo-spiral k-t undersampling with respiratory motion-informed locally low-rank (MI-LLR) reconstruction for robust whole-heart myocardial quantitative perfusion CMR in an experimental pig model of myocardial infarction. As reference, standard 2D acquisitions are used. Overall, image quality scoring was good. Perfusion defects were equally well depicted and discernible in imaging and MBF perfusion mapping in 3D and 2D approaches, respectively.
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