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Abstract #1011

Clinical evaluation and reproducibility of 3D whole-heart free-breathing joint T1/T2 quantification with isotropic resolution.

Carlos Velasco1, Alina Hua1, Anastasia Fotaki1, Camila Munoz1, Giorgia Milotta1, Karl P. Kunze1,2, Radhouene Neji1,2, Tevfik F. Ismail1, Claudia Prieto1, and Rene M. Botnar1
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom


Myocardial tissue characterization including quantification of fibrosis and oedema plays an important role in the evaluation of many myocardial diseases. T1 and T2 maps are typically acquired sequentially in 2D under several breath-holds. However, misregistration artifacts, spatial resolution and volumetric coverage remain a limitation. To address this, a high resolution, 3D whole-heart motion-compensated joint T1/T2 water/fat sequence has been proposed and validated in a phantom and in healthy subjects. Here, we demonstrate the feasibility of the proposed approach to simultaneously acquire whole-heart co-registered T1, T2 maps as well as water and fat volumes in ~9min in patients with cardiovascular disease.

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