Purpose: whole brain in vivo detection of GABA/GABA+ using SLOW-editing at 7T.
Methods: An EPSI-based B0/B1+ robust SLOW-editing was applied in four healthy subjects. Pure GABA was measured by two different macromolecular-nulling inversion recovery pulses, namely a broadband- and a narrowband-inversion pulse.
Results: the editing GABA/GABA+ signal at 3.01 ppm are presented. The signal intensity of GABA/GABA+ ratio is 40 – 60%.
Conclusions: whole-brain in vivo GABA/GABA+-editing can be performed using SLOW-EPSI in around 10 minutes measurement time and is therefore clinically applicable.