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Abstract #1032

SLOW-editing for GABA/GABA+ MRSI at 7T

Guodong Weng1,2, Piotr Radojewski1,2, and Johannes Slotboom1,2
1Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, 2Translational Imaging Center, sitem-insel AG, Bern, Switzerland


Purpose: whole brain in vivo detection of GABA/GABA+ using SLOW-editing at 7T.

Methods: An EPSI-based B0/B1+ robust SLOW-editing was applied in four healthy subjects. Pure GABA was measured by two different macromolecular-nulling inversion recovery pulses, namely a broadband- and a narrowband-inversion pulse.

Results: the editing GABA/GABA+ signal at 3.01 ppm are presented. The signal intensity of GABA/GABA+ ratio is 40 – 60%.

Conclusions: whole-brain in vivo GABA/GABA+-editing can be performed using SLOW-EPSI in around 10 minutes measurement time and is therefore clinically applicable.

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