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Abstract #1033

Simultaneous J-difference editing of GABA and GSH with extended echo-times using ExTE-HERMES

Peter Truong1 and Jamie Near1,2
1Physical Sciences Research Platform, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada, 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada


J-difference editing techniques, such as MEGA-PRESS, are often used to detect gamma-aminobutryic acid (GABA) and glutathione (GSH). However, two separate scans are needed to acquire both metabolites. The HERMES editing scheme does address this issue, allowing simultaneous acquisition of GABA and GSH. Even then, there are limitations as the optimal echo time (TE) can only be set for one metabolite at the expense of lower editing efficiency for the other. We propose the Extended TE (ExTE) HERMES editing scheme, which allows us to acquire edited spectra at TE=120ms, ensuring maximum GSH signal while still providing efficient GABA editing.

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