Multi-shot (MS) reduces image distortion in EPI caused by B0 field inhomogeneity and enables higher resolution diffusion imaging. However, interaction between physiologic motion and diffusion encoding gradients leads to strong image aliasing artifacts in MS-EPI due to phase discrepancies. We propose prospective strategies to reduce shot-to-shot phase variation for interleaved phase-segmented diffusion MS-EPI. First and second order motion compensated diffusion gradient waveforms and dual-speed EPI with oversampled k-space center were evaluated as a shot-to-shot phase mitigation strategy. Validations were performed in silico, in vitro, and in vivo in the brain, liver, and heart.
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