Most white matter voxels are comprised of a combination of microstructurally different tracts that kiss and cross. Conventional MRI contrasts that provide a single measurement per voxel fail to disentangle the microstructural properties of these tracts. Co-encoding diffusion with a complementary contrast offers additional insight into each tract’s individual contribution. Here we present a novel MT-prepared diffusion sequence, optimized for contrast in both MTR and orientation, acquired within a clinically acceptable scan time of under 7 min. The goal is to provide a data acquisition framework for the computation of tract-specific myelin indices and potentially more structurally specific connectomes.
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