Dual-encoding of magnetization transfer and diffusion for the characterization of tract-specific myelination
Ilana R Leppert1, Christopher D Rowley1,2, Jennifer SW Campbell1, Mark Nelson1,3, Bruce G Pike4, and Christine L Tardif1,2,3
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 2Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, 3Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 4Hotchkiss Brain Institute and Departments of Radiology and Clinical Neuroscience, University of Calgary, Calgary, Canada, Calgary, AB, Canada
Most white matter voxels are comprised of a combination of microstructurally different tracts that kiss and cross. Conventional MRI contrasts that provide a single measurement per voxel fail to disentangle the microstructural properties of these tracts. Co-encoding diffusion with a complementary contrast offers additional insight into each tract’s individual contribution. Here we present a novel MT-prepared diffusion sequence, optimized for contrast in both MTR and orientation, acquired within a clinically acceptable scan time of under 7 min. The goal is to provide a data acquisition framework for the computation of tract-specific myelin indices and potentially more structurally specific connectomes.
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