Magnetic susceptibility induces morphology- and orientation-dependent perturbations of the $$$B_0$$$-field and hence the DWI signal. At the micro-structural scale of brain white matter, the main contribution to these perturbations comes from myelin. To understand how the perturbations are shaped by the intrinsically undulating morphology of axons, observed in 3D reconstructions of synchrotron imaging and electron microscopy, we have implemented a framework that enables us to systematically study how undulation affects the orientation-dependency of susceptibility-induced B-field inhomogeneity, and how this affects the DWI signal - both in the intra- and extra-axonal compartments.
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