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Abstract #1048

Evaluating Within-Subject Test-Retest Replicability of Free-Water Corrected and Uncorrected Multi-Shell Diffusion MRI Measures.

Virendra R Mishra1, Ofer Pasternak2, Karthik R Sreenivasan1, and Dietmar Cordes1
1Imaging, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Harvard Medical School, Boston, MA, United States


Free-water (FW) estimation could be improved with higher spatial resolution diffusion MRI (dMRI) data acquired at multiple shells. However, the effect of multi-shell protocol features on the accuracy of estimating FW and FW-corrected fractional anisotropy (FA) across the brain structures is currently unknown. We evaluated test-retest reproducibility of FW and FW-corrected FA across 20 major white-matter tracts across four dMRI protocols, two protocols with ADNI-3 and two protocols with HCP sequences. Our analysis suggests higher spatial resolution HCP-style dMRI data acquisition with correction of FW-estimation could be reliably performed in routine clinical investigations.

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