Triple Multinuclear Probe: Expanding the Throughput and Versatility of a dDNP Polarizer
Thanh Phong Lê1,2, Emma Wiström2, Jean-Noël Hyacinthe1, and Andrea Capozzi2,3
1Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, 2Laboratory of Functional and Metabolic Imaging, EPFL (Swiss Federal Institute of Technology in Lausanne), Lausanne, Switzerland, 3Department of Health Technology, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Kgs Lyngby, Denmark
Low throughput is one of dDNP main shortcomings. Here, we present the design and performance of a triple DNP probe, which not only allows multiple samples to be hyperpolarized simultaneously, but also to distinctly monitor the solid-state polarization of each sample, even when prepared with different nuclei and radicals. This versatile high throughput probe allows parallel solid-state sample characterization, as well as sequential injections of distinct tracers to probe multiple biomarkers, thus enabling more advanced in-vivo experimental designs.
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