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Abstract #1063

Lactate excitation limits bicarbonate detection in hyperpolarized pyruvate MRI of the brain

Nikolaj Bøgh1, Camilla W Rasmussen1, Lotte B Bertelsen1, Esben SS Hansen1, and Christoffer Laustsen1
1Aarhus University, Aarhus, Denmark


In hyperpolarized [1-13C]pyruvate MRI of the brain, pyruvate-to-bicarbonate conversion, representing oxidative metabolism, is detected at low levels, despite the highly oxidative metabolism of the brain. We sought to determine the effect of lactate excitation on bicarbonate detection in healthy rats imaged in a cross-over fashion (lactate flip angle = 90° or 0°). In the brain, the bicarbonate signal-to-noise ratio increased 65 % when lactate was not excited. This effect was not observed in the heart, kidneys or liver. Collectively, our data show that lactate saturation limits bicarbonate detection in the brain solely, which has implications for study designs.

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