Seiffert spirals for hyperpolarized 13C MRI with efficient k-space sampling and flexible acceleration
Rie Beck Olin1, Tobias Speidel2, Juan Diego Sánchez-Heredia1, Esben S Hansen3, Christoffer Laustsen3, Lars G Hanson1,4, Volker Rasche5, and Jan Henrik Ardenkjær-Larsen1
1Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Core Facility Small Animal MRI, University of Ulm, Ulm, Germany, 3MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 4Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 5Department of Internal Medicine II, University of Ulm, Ulm, Germany
The Seiffert spirals trajectory has favorable properties for hyperpolarized 13C MRI. It allows for high degrees of undersampling and combined conjugate gradient compressed sensing SENSE reconstruction when multi-channel arrays are used. The trajectory was evaluated in simulations, in phantom, and for in vivo hyperpolarized 13C-urea MRI of pig kidneys with retrospective undersampling and high temporal resolution. For single-frequency imaging, flexible acceleration is achieved through reconstruction based on any number and combination of spiral arms. Simulations demonstrated noise-like aliasing and successful reconstruction. The in vivo experiment showed improved characterization of urea dynamics after undersampling. The reconstruction algorithm can be further improved.
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