Parallel imaging of hyperpolarized 13C MRI using 23Na sensitivity profiles
Rie Beck Olin1, Juan Diego Sánchez-Heredia1, James T Grist2,3,4,5, Wenjun Wang6, Nikolaj Bøgh7, Vitaliy Zhurbenko6, Esben S Hansen7, Rolf F Schulte8, Damian Tyler2,3, Christoffer Laustsen7, and Jan Henrik Ardenkjær-Larsen1
1Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 3Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 4Department of Radiology, Oxford University Hospitals Trust, Oxford, United Kingdom, 5Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, 6Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark, 7MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 8GE Healthcare, Munich, Germany
Parallel imaging can aid hyperpolarized 13C MRI in extracting more information in the limited time window of the hyperpolarized signal. Using a dedicated, flexible 13C receive coil design with coupling coefficients matched for both 13C and 23Na, sensitivity profiles for reconstruction can be acquired at the 23Na frequency. We demonstrate this method in two hyperpolarized in vivo experiments involving pig kidneys and human brain using a two-times accelerated 3D blipped stack-of-spirals sequence with dual-resolution. The results show good SNR, coverage, and resolution. The method is promising for integrating and automating parallel imaging for hyperpolarized 13C MRI.
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