Abstract #1067
Evidence of Lactate Shuttling in the Human Brain with Hyperpolarized 13C-MRI
Biranavan Uthayakumar1, Nadia Bragagnolo2, Hany Soliman3, Albert P Chen4, Ruby Endre5, William J Perks6, Nathan Ma6, Chris Heyn7, Sandra E Black8, and Charles H Cunningham5
1Medical Biophysics, University of Toronto, Mississauga, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Radiation oncolocy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4GE Healthcare, Toronto, ON, Canada, 5Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 6Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 7Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 8Neurology and Hurvitz Brain Sciences Research Program Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Synopsis
It is well known that glucose is the primary source of energy in the brain, but mounting evidence suggests that at least some of this glucose is first converted to lactate and shuttled between cellular compartments before being oxidized in the TCA cycle. In this study, the hypothesis that this ”lactate shuttle” contributes to the 13C-lactate and 13C-bicarbonate signal observed in the awake human brain is tested using hyperpolarized 13C MRI (HP13C-MRI).
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