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Abstract #1066

Liver and heart metabolism of [1-13C]-pyruvate in awake and anesthetized rats

Viivi Hyppönen1, Jessica Rosa1, and Mikko Kettunen1
1A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland


Anesthesia has profound effects on overall metabolism, leading to significant signal changes in metabolic MR brain experiments using hyperpolarized [1-13C]pyruvate. In the current study, we studied the possible origins of the signals from rat liver and heart under isoflurane anesthesia and while the animals were awake. Increased metabolite signals, especially lactate, were observed from both organs in awake animals.

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