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Abstract #1065

Modelling the kinetics of cerebral lactate production after hyperpolarized [2H7, U-13C6]-D-glucose bolus

Emmanuelle Flatt1, Bernard Lanz1, Thanh Phong Lê1,2, Rolf Gruetter1, and Mor Mishkovsky1
1Laboratory for Functional and Metabolic Imaging (LIFMET), EPFL, Lausanne, Switzerland, 2Geneva School of Health Sciences, University of Applied Sciences and Arts Western Switzerland (HES-SO), Geneva, Switzerland


The present work describes a quantitative analysis of lactate 13C-labeling pattern following the metabolism of hyperpolarized [2H7,U-13C6]-D-glucose. This lactate production results from 12 biochemical steps including glucose transport, 10 enzymatic steps of glycolysis, and LDH mediated pyruvate-to-lactate conversion. The 3-compartment model description was found a good compromise to interpret the hyperpolarized metabolic curves. This demonstrates the potential of hyperpolarized [2H7, U-13C6]-D-glucose as a new biochemical probe for brain energy metabolism.

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