The present work describes a quantitative analysis of lactate 13C-labeling pattern following the metabolism of hyperpolarized [2H7,U-13C6]-D-glucose. This lactate production results from 12 biochemical steps including glucose transport, 10 enzymatic steps of glycolysis, and LDH mediated pyruvate-to-lactate conversion. The 3-compartment model description was found a good compromise to interpret the hyperpolarized metabolic curves. This demonstrates the potential of hyperpolarized [2H7, U-13C6]-D-glucose as a new biochemical probe for brain energy metabolism.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords