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Abstract #1079

Reproducibility of localized 31P-MRS methods using different surface coils for assessment of hepatic metabolism in vivo at 3T

Marc Jonuscheit1,2, Stefan Wierichs1,2, Yuliya Kupriyanova1,2, Michael Roden1,2,3, and Vera Schrauwen-Hinderling1,2,4
1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany, 2German Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany, 3Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, 4Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands


We determined day-to-day variation and intra-session reproducibility of 31P-MRS-based hepatic phosphorus metabolite quantification. To this end, we compared a standard single loop with a custom-created quadrature surface coil. Absolute concentrations of γ-adenosine triphosphate and inorganic phosphate were assessed in 7 volunteers with both coils. Both coils showed comparable day-to-day and intra-session CVs < 10 %. Metabolite concentrations determined by the two coils were similar. Therefore, both coils yield robust absolute concentrations of hepatic phosphorous metabolites. The quadrature coil allows measurements at a higher distance from the coil which can be important for the application in obese patients.

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