We demonstrate that, even without having water as an internal reference, a combination of spectral registration and fitting can restore artificial signal loss promoted by incoherent averaging due to frequency/phase drifts and motion-induced dephasing for the cardinal brain metabolites (tCr, tCho, tNAA, Glx and Ins) by using a set of synthetically distorted diffusion MR spectra (including realistic phase, frequency and amplitude fluctuations).
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