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Abstract #1078

Improved motion compensation for water-suppressed diffusion MR Spectroscopy evaluated using synthetic data

André Döring1, Derek K Jones1, and Roland Kreis2,3
1Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 2Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University Bern, Bern, Switzerland, 3Translational Imaging Center, sitem-insel, Bern, Switzerland


We demonstrate that, even without having water as an internal reference, a combination of spectral registration and fitting can restore artificial signal loss promoted by incoherent averaging due to frequency/phase drifts and motion-induced dephasing for the cardinal brain metabolites (tCr, tCho, tNAA, Glx and Ins) by using a set of synthetically distorted diffusion MR spectra (including realistic phase, frequency and amplitude fluctuations).

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