Abstract #1078

Improved motion compensation for water-suppressed diffusion MR Spectroscopy evaluated using synthetic data

André Döring¹, Derek K Jones¹, and Roland Kreis^2,3

¹Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, ²Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University Bern, Bern, Switzerland, ³Translational Imaging Center, sitem-insel, Bern, Switzerland

Synopsis

We demonstrate that, even without having water as an internal reference, a combination of spectral registration and fitting can restore artificial signal loss promoted by incoherent averaging due to frequency/phase drifts and motion-induced dephasing for the cardinal brain metabolites (tCr, tCho, tNAA, Glx and Ins) by using a set of synthetically distorted diffusion MR spectra (including realistic phase, frequency and amplitude fluctuations).

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