Abstract #1081

Functional changes in GABA during motor learning with GABA-editing at 3T

Tiffany K Bell^1,2,3, Alexander R Craven^4,5, Kenneth HugDahl^4,6,7, Ralphe Noeske⁸, and Ashley D Harris^1,2,3

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, ⁵Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, ⁶Division of Psychiatry, Haukeland University Hospital, Bergen, Norway, ⁷Department of Radiology, Haukeland University Hospital, Bergen, Norway, ⁸GE Healthcare, Berlin, Germany

Synopsis

Functional magnetic resonance spectroscopy (fMRS) of GABA at 3T is challenging due to the difficulties of measuring GABA levels; GABA is present in the brain at relatively low concentrations and its signal is overlapped by higher concentration metabolites. Here we use a continuous MEGA-PRESS acquisition to show changes in GABA levels measured in the sensorimotor cortex during motor learning and during a control button pressing task. This indicates GABA levels can be tracked during a functional experiment, allowing fMRS of GABA to be accessible at 3T, the more commonly used field strength.

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