Functional changes in GABA during motor learning with GABA-editing at 3T
Tiffany K Bell1,2,3, Alexander R Craven4,5, Kenneth HugDahl4,6,7, Ralphe Noeske8, and Ashley D Harris1,2,3
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 4Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, 5Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 6Division of Psychiatry, Haukeland University Hospital, Bergen, Norway, 7Department of Radiology, Haukeland University Hospital, Bergen, Norway, 8GE Healthcare, Berlin, Germany
Functional magnetic resonance spectroscopy (fMRS) of GABA at 3T is challenging due to the difficulties of measuring GABA levels; GABA is present in the brain at relatively low concentrations and its signal is overlapped by higher concentration metabolites. Here we use a continuous MEGA-PRESS acquisition to show changes in GABA levels measured in the sensorimotor cortex during motor learning and during a control button pressing task. This indicates GABA levels can be tracked during a functional experiment, allowing fMRS of GABA to be accessible at 3T, the more commonly used field strength.
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