Abstract #1084
Replicability of 1H MR spectroscopic imaging in mild traumatic brain injury
Anna M Chen1, Teresa Gerhalter1, Seena Dehkharghani1,2, Rosemary Peralta1, Fatemeh Adlparvar1, Martin Gajdošík1, Mickael Tordjman1,3, Julia Zabludovsky1, Sulaiman Sheriff4, Sinyeob Ahn5, James S Babb1, Tamara Bushnik6, Alejandro Zarate6, Jonathan M Silver7, Brian S Im6, Stephen P Wall8, Guillaume Madelin1, and Ivan I Kirov1,2,9
1Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 3Department of Radiology, Cochin Hospital, Paris, France, 4Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, 5Siemens Medical Solutions USA Inc., Malvern, PA, United States, 6Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States, 7Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, 8Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, New York, NY, United States, 9Center for Advanced Imaging Innovation and Research, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States
Synopsis
1H-MRS has the potential to provide biomarkers for mild traumatic brain injury (mTBI), a diagnosis in which damage is often imaging-occult, but a lack of replicability and reproducibility studies hampers clinical translation. Here, we tested the replicability of previous MRSI results in mTBI with a different patient cohort. Five out of seven hypotheses were consistent with previous work, with key findings of globally diffuse white matter (WM) injury and limited gray matter injury. However, we report differences in choline and creatine, not N-acetyl-aspartate. Correlations were found between metabolite levels in WM and both symptomatology and neuropsychological testing.
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