The non-invasive detection of 2-hydroxyglutarate (2HG) via 1H MRS is of particular interest in brain tumors, but quantification of 2HG may be challenging due the spectral overlap with Glutamate and Glutamine. In this study, we implemented a simulation framework for the assessment of the quantification reliability for 2HG under realistic conditions, and demonstrated its application to a PRESS sequence at B0=9.4T with a representative set of different TEs and SNR levels. With this framework, we aim to identify optimal acquisition parameters for the detection of 2HG in glioma mouse models at a 9.4-T small animal scanner in the future.
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