Functional MRI in the entorhinal cortex is very challenging due to large and geometrically complex B0 field inhomogeneity. As a result, a quarter of voxels are lost due to T2*-driven dephasing and/or because the echo is pushed outside of the acquisition window. Additionally, off-resonant voxels suffer from poor excitation efficiency with frequency-selective binomial pulse excitation, which are preferred for fat suppression for SAR and time efficiency. We empirically demonstrate substantial signal, and consequently tSNR, gains in off-resonance regions by reducing binomial pulse order (from 1-3-3-1 to 1-2-1 or 1-1) that match numerical predictions.
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