SpinalCompCor: PCA-based denoising for spinal cord fMRI
Kimberly J. Hemmerling1,2, Mark A. Hoggarth2, Todd Parrish3, Robert L. Barry4,5,6, and Molly G. Bright1,2
1Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Physical Therapy & Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3Department of Radiology, Northwestern University, Chicago, IL, United States, 4Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 5Department of Radiology, Harvard Medical School, Boston, MA, United States, 6Harvard–Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, MA, United States
SpinalCompCor is a denoising technique in which principal component (PC) analysis is performed in a region outside of the spinal cord to define nuisance regressors. Temporal SNR was greater when PC regressors were included in the general linear model, compared to when they were regressed out of the data prior to motion correction. In comparing models that vary the number of PC regressors, models with multiple PCs generally performed better than those with single PCs. SpinalCompCor is a promising technique for spinal cord fMRI denoising.
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