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Abstract #1122

White matter hyperintensities and their dynamic nature: diffusion MRI analysis of white matter hyperintensity regression

Angela CC Jochems1,2, Susana Muñoz Maniega1, Una Clancy1,2, Daniela Jaime Garcia1,2, Stewart Wiseman1,2, Gordon W Blair1, Rosalind Brown1,2, Ellen V Backhouse1,2, Carmen Arteaga1,2, Will Hewins1,2, Eleni Sakka1,2, Agniete Kampaite1,2, Michael S Stringer1,2, Michael J Thrippleton1,2, Mark E Bastin1, Maria Valdés Hernández1,2, Ian Marshall1, Fergus N Doubal1,2, and Joanna M Wardlaw1,2
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom


White matter hyperintensities (WMH) have been shown to progress over time but they might regress too. Little is known about the regression of WMH as the main focus has been on progression. We investigate WMH regression and their dynamic properties using diffusion MRI. Areas of WMH change, both progression and regression, might have different tissue integrity properties than areas that are more stable, i.e. stable normal-appearing white matter (NAWM), become more hyperintense, or stable WMH. Mean diffusivity and peak width of skeletonized mean diffusivity (PSMD) might be most sensitive to subtle integrity changes before they become visible on structural MRI.

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