Abstract #1126

Quantitative Susceptibility Mapping and R2* Mapping Suggest Demyelination in Silent Cerebral Infarcts in Sickle Cell Anaemia

Russell Murdoch¹, Hanne Stotesbury², Jamie Kawadler², Dawn Saunders², Fenella Kirkham², and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Imaging and Biophysics, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

Synopsis

To investigate the composition of silent cerebral infarcts (SCI) in sickle cell anaemia (SCA), we compared the magnetic susceptibility (χ) and transverse relaxation rates (R2*) of segmented SCI lesions to normal appearing white matter (NAWM) in the contralateral hemisphere. In 37 SCA subjects and 8 healthy controls (HC), SCI lesions were significantly less diamagnetic and had significantly lower R2* relative to NAWM. The χ and R2* changes indicate demyelination within the lesions. R2* mapping suggests that SCI lesions are more demyelinated in the SCA subjects, relative to HC, likely due to the haemodynamic challenges associated with the condition.

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