Abstract #1127

Preservation of Brain Oxygen Metabolism in Emerging Young Adult Survivors of Fontan Palliation for Single Ventricle.

Jian Shen¹, Silvie Suriany², Clio Gonzalez-Zaccarias³, Botian Xu¹, Ashok Panigraphy⁴, Jon Detterich², and John C Wood⁵

¹Bioengineering, University of Southern California, Los Angeles, CA, United States, ²Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States, ³Neurosciences, University of Southern California, Los Angeles, CA, United States, ⁴Radiology, Children's Hospital Pittsburgh, Pittsburgh, PA, United States, ⁵Pediatrics, Children's Hospital of Los Angeles-USC KSOM, Los Angeles, CA, United States

Synopsis

Surgical palliation of single ventricular heart disease (Fontan procedure) leads to poor cardiac output, high central venous pressures, and long-term multiorgan morbidity. We report cerebral blood flow, brain oxygen delivery, and cerebral metabolic rate in 20 Fontan survivors and 9 control subjects. Fontan patients had lower cerebral blood flow and oxygen saturation but maintained cerebral oxygen delivery and cerebral metabolic rate of oxygen (CMRO₂) because of polycythemia. Scattergram between CMRO₂ and O₂ delivery suggests similar oxygen extraction at the microvascular level in both groups. Taken together, these data suggest adequate cerebrovascular compensation to low cardiac output in Fontan patients.

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