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Abstract #1128

Neurogenic metabolites after intravenous autologous stem cells infusion in Stroke: a high resolution  NMR spectroscopic analysis of human sera

Ashu Bhasin1, Pawan Kumar2, S Senthil Kumaran2, Sujeet Mewar2, and MV Padma Srivastava1
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, 2Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India


High resolution NMR spectroscopy to study the neural and cellular metabolites from serum samples of 14 chronic stroke patients after autologous bone marrow derived mononuclear stem cells and neurorehabilitation using 700 MHz NMR spectrometer. The data were processed using the Agilent software, Vnmrj2.3A. PLS-DA multivariate analysis was performed to explore biochemical shifts and upregulation between patients with stem cell infusion and controls. Using MetaboAnalyst (3.0) software, we observed elevated levels of myoinositol, choline, NAA, ML in one group 1 as compared to group 2 (groups undisclosed).

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