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Abstract #1134

Creatine chemical exchange saturation transfer (CrCEST) MRI reproducibility in healthy adults at 3T

Zane Coleman1, Ayaz Khan1, Shubo Wang1, Pat Hanby1, Donald Wallace1, Zoltan Patay1, and Puneet Bagga1
1Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States


CrCEST MRI indirectly measures creatine as it exchanges amine (-NH2) protons with free water in the skeletal muscle. When performed on the calf after plantar flexion exercise, creatine recovery data can be obtained in all four major calf muscles. While 2D CrCEST has been performed in adults before, no studies showing its reproducibility have been published. Here, we show that the essential muscles in plantar flexion movement, gastrocnemius muscles, in the calf are candidates for reproducible CrCEST data.

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