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Abstract #1142

Impact of the B0 and B1+-adjustments on the in vivo metabolite quantification accuracy of simultaneous 2voxel 1H brain MRS at 7T

Layla Tabea Riemann1, Christoph Stefan Aigner1, Ralf Mekle2, Sebastian Schmitter1,3,4, Bernd Ittermann1, and Ariane Fillmer1
1Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 2Center for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany


For simultaneous multi-voxel spectroscopy (sMVS), it is necessary to optimize the B0 shimming and the B1+ adjustment simultaneously for two voxels. The impact of these adjustments on the smallest possible distance for simultaneous two-voxel MRS acquisitions is determined by Bloch simulations, and the influence on the spectral quality is assessed for three different brain regions. To this end, the previously introduced 2 spin-echo full-intensity acquired localization (2SPECIAL) sequence and the voxel-GeneRalized Autocalibrating Partial Parallel Acquisition (vGRAPPA) decomposition algorithm are utilized to simultaneously acquire and retrospectively decompose in vivo brain 1H-MRS data from two voxels at short echo times at 7T.

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