For simultaneous multi-voxel spectroscopy (sMVS), it is necessary to optimize the B0 shimming and the B1+ adjustment simultaneously for two voxels. The impact of these adjustments on the smallest possible distance for simultaneous two-voxel MRS acquisitions is determined by Bloch simulations, and the influence on the spectral quality is assessed for three different brain regions. To this end, the previously introduced 2 spin-echo full-intensity acquired localization (2SPECIAL) sequence and the voxel-GeneRalized Autocalibrating Partial Parallel Acquisition (vGRAPPA) decomposition algorithm are utilized to simultaneously acquire and retrospectively decompose in vivo brain 1H-MRS data from two voxels at short echo times at 7T.
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