Comparison of pCASL, DSC and FAIR for Cerebral Perfusion in Rats @9.4T
Lisa Y Hung1, Karl-Heinz Herrmann1, Renat Sibgatulin1, Lydiane Hirschler2,3, Jan Warnking3, Emmanuel L Barbier3, Otto W Witte4, Knut Holthoff4, Jürgen R Reichenbach1, and Alexander Joerk4
1Medical Physics Group, Institute of Diagnostic Radiology, Jena University Hospital, Jena, Germany, 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Grenoble Institut Neurosciences, Univ. Grenoble Alpes, Inserm, U1216, Grenoble, France, 4Hans-Berger Department of Neurology, Jena University Hospital, Jena, Germany
Attaining reproducible, time-efficient, high spatial resolution and quantitative MRI perfusion images in small animal MRI @9.4T is still challenging. To take a step toward this goal, perfusion data from arterial spin labeling (ASL), Flow-sensitive Alternating Inversion Recovery (FAIR), dynamic susceptibility contrast (DSC), and pseudo-continuous arterial spin labeling (pCASL) sequences are compared by assessing cerebral perfusion in 5 rats, each scanned 3 times. Differences in (cerebral blood flow) CBF in major brain regions were analyzed, and the repeatability of perfusion MRI was assessed.
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