Abstract #1144

Comparison of pCASL, DSC and FAIR for Cerebral Perfusion in Rats @9.4T

Lisa Y Hung¹, Karl-Heinz Herrmann¹, Renat Sibgatulin¹, Lydiane Hirschler^2,3, Jan Warnking³, Emmanuel L Barbier³, Otto W Witte⁴, Knut Holthoff⁴, Jürgen R Reichenbach¹, and Alexander Joerk⁴

¹Medical Physics Group, Institute of Diagnostic Radiology, Jena University Hospital, Jena, Germany, ²Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Grenoble Institut Neurosciences, Univ. Grenoble Alpes, Inserm, U1216, Grenoble, France, ⁴Hans-Berger Department of Neurology, Jena University Hospital, Jena, Germany

Synopsis

Attaining reproducible, time-efficient, high spatial resolution and quantitative MRI perfusion images in small animal MRI @9.4T is still challenging. To take a step toward this goal, perfusion data from arterial spin labeling (ASL), Flow-sensitive Alternating Inversion Recovery (FAIR), dynamic susceptibility contrast (DSC), and pseudo-continuous arterial spin labeling (pCASL) sequences are compared by assessing cerebral perfusion in 5 rats, each scanned 3 times. Differences in (cerebral blood flow) CBF in major brain regions were analyzed, and the repeatability of perfusion MRI was assessed.

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