Given its central role in substrate metabolism, the ability to quantify muscle glycogen (Gly) continuously and noninvasively using natural abundance 13C MR spectroscopy presents an important opportunity for understanding human metabolism. This study evaluated the reproducibility of Gly measured by 13C MRS in the quadriceps muscle using three methods for signal standardization at 3T: Gly/total creatine (TCr) from 13C, Gly/TCr using 13C and 1H, and Gly/water. The novel results from this study suggest that Gly/TCr measurements using the creatine peak from 1H MRS is highly reproducible and may be an advantageous approach to measuring muscle glycogen in the future.
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