The editing capabilities of the MEGA-PRESS sequence are combined with diffusion-weighing to enable both quantification and diffusion measurements of less abundant brain metabolites. The technique, labelled DW-MEGA-PRESS, was tested for combined editing and diffusion-weighting of GABA. Obtained data give reliable results for GABA concentrations and corresponding diffusion coefficients from in vitro experiments. When applied to in vivo acquisitions, reliable diffusion coefficients for the dominating metabolites were obtained. GABA could be reliably quantified, but the signal-to-noise ratio was not sufficient for a reliable determination of its diffusion coefficient. This could be improved by further optimization of scanning and post-processing protocols.