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Abstract #1153

Simultaneous Measurement of Glu and GABA at 7T

Tal Finkelman1, Edna Furman-Haran2, Rony Paz3, and Assaf Tal1
1Chemical and Biological Physics, Weizmann, Rehovot, Israel, 2Life Sciences Core Facilities, Weizmann, Rehovot, Israel, 3Brain Sciences, Weizmann, Rehovot, Israel


Glutamate (Glu) and γ‑aminobutyric-acid (GABA) are central neurotransmitters participating in many cognitive processes, and their combined measurement is of great relevance. Proton Magnetic Resonance Spectroscopy (1H-MRS) allows the no–invasive, in-vivo, measurement of GABA and Glu. At magnetic fields below 7T, GABA is detected by spectral editing strategies, while Glu is detected by non-editing strategies. We compared both edited and non‑edited approaches at 7T for simultaneously quantifying Glu and GABA from 21 volunteers, and found that non-edited sequences at TE=80ms provide better combined-reproducibility than either edited sequences at the same TE, or non-edited sequence at a shorter TE (42ms).

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