Glutamate (Glu) and γ‑aminobutyric-acid (GABA) are central neurotransmitters participating in many cognitive processes, and their combined measurement is of great relevance. Proton Magnetic Resonance Spectroscopy (1H-MRS) allows the no–invasive, in-vivo, measurement of GABA and Glu. At magnetic fields below 7T, GABA is detected by spectral editing strategies, while Glu is detected by non-editing strategies. We compared both edited and non‑edited approaches at 7T for simultaneously quantifying Glu and GABA from 21 volunteers, and found that non-edited sequences at TE=80ms provide better combined-reproducibility than either edited sequences at the same TE, or non-edited sequence at a shorter TE (42ms).
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