We describe a comprehensive pipeline for super-resolution reconstruction of clinical diffusion-weighted MRIs acquired with isotropic diffusion encoding (IDE), or spherical tensor encoding. The pipeline integrates blip-up/down EPI distortion correction and slice-to-volume registration (SVR). Multiple low-resolution IDE-MRIs with different slice orientations relative to the brain are processed to reconstruct high-resolution IDE-MRIs. From high-resolution IDE-MRIs with a wide range of b-values we estimate spectra of subvoxel MD values to describe the distribution of water mobilities in microscopic brain tissue microenvironments. Integrating SVR-reconstruction with IDE is an important step in the clinical translation of MD spectroscopic MRI for fetal MRI applications.
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