Comparison of in vivo hepatic metabolic quantitation by localized 31P MRS at 7T
Lorenz Pfleger1,2, Wolfgang Bogner2, Albrecht Ingo Schmid3, Thomas Scherer1, Peter Wolf1, Michael Krebs1, and Martin Krššák1,4
1Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria, 2High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 3High Field MR Centre, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 4Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria
This study focuses on the comparison of different in vivo data-acquisitions for quantifying hepatic 31P metabolite concentrations using a phantom replacement method. We have compared a 1D-slab localized DRESS, a single-voxel-spectroscopy (SVS) ISIS as well as a 3D-CSI 31P MRS acquisition at 7T. Each method has its own advantages and disadvantages and needs to be chosen according to the focus and design of the study.
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