A spectrally-interleaved semi-adiabatic magnetic resonance spectroscopic imaging sequence was developed to simultaneously acquire water and metabolite resonances within the same repetition time. A water interleave enables eddy current correction, absolute quantification through water reference and thermometry using empirically-derived formulae based on chemical shifts of temperature-sensitive water and temperature-insensitive metabolites. The sequence successfully acquired both 1-minute single voxel and 4-minute multi-voxel acquisitions in phantom and in vivo, producing temperature estimates of 21.2 °C, and 35.7 °C, respectively. LCModel fitting of metabolites provided reliable fitting of multiple metabolite peaks including separation of glutamate and glutamine.
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