There is a need for biomarkers to guide appropriate treatment in patients with clinical features of both asthma and COPD. A broadly-defined population of 164 patients with asthma and/or COPD taking part in the NOVELTY study were recruited from primary care and scanned with 129Xe MRI (ventilation, acinar microstructure and gas exchange measurements). 129Xe MRI global and regional metrics showed significant differences between patients with asthma, asthma+COPD and COPD. 129Xe MRI metrics remained sensitive to diagnosis sub-groups when only patients with normal pulmonary function tests were considered.
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