Abstract #1168
Hyperpolarized 129Xe MRI and spectroscopy in healthy control subjects reveals age-related changes in measurements of pulmonary gas exchange
David Mummy1, Aparna Swaminathan2, Elianna Bier3, Kevin Yarnall4, Aryil Bechtel5, Junlan Lu6, Suphachart Leewiwatwong6, Sakib Kabir1, Jennifer Korzekwinski1, and Bastiaan Driehuys1,3,6
1Radiology, Duke University, Durham, NC, United States, 2Medicine, Duke University, Durham, NC, United States, 3Biomedical Engineering, Duke University, Durham, NC, United States, 4Mechanical Engineering, Duke University, Durham, NC, United States, 5Physics, Duke University, Durham, NC, United States, 6Medical Physics, Duke University, Durham, NC, United States
Synopsis
Age-related changes in 129Xe gas exchange MRI and spectroscopy are not well understood. We assessed a suite of common 129Xe-derived measures of gas exchange function in a population of healthy control subjects age 19-87. Increased age was associated with reduced red blood cell (RBC) to barrier ratio and with greater levels of ventilation defects and RBC transfer defects. These effects must be accounted for when evaluating 129Xe-derived metrics as markers of disease in individual patients. Notably, high barrier uptake remained largely minimal across age groups, and does not appear to be a feature of healthy aging.
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