Age-related changes in 129Xe gas exchange MRI and spectroscopy are not well understood. We assessed a suite of common 129Xe-derived measures of gas exchange function in a population of healthy control subjects age 19-87. Increased age was associated with reduced red blood cell (RBC) to barrier ratio and with greater levels of ventilation defects and RBC transfer defects. These effects must be accounted for when evaluating 129Xe-derived metrics as markers of disease in individual patients. Notably, high barrier uptake remained largely minimal across age groups, and does not appear to be a feature of healthy aging.
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