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Abstract #1169

Dissolved 129Xe spectroscopy in the lungs of preterm-born children

Ho-Fung Chan1, Guilhem J Collier1, Laurie J Smith1, Alberto M Biancardi1, Jody Bray1, Helen Marshall1, Paul J.C Hughes1, Madhwesha Rao1, Graham Norquay1, Andrew J Swift1, Kylie Hart2,3, Michael Cousins2,3, Sailesh Kotecha2,3, and Jim M Wild1
1Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Child Health, Cardiff University School of Medicine, Cardiff, United Kingdom, 3Neonatal Unit, Cardiff and Vale University Health Board, Cardiff, United Kingdom


Ventilation defects and increased alveolar heterogeneity have been observed previously with 129Xe MRI in preterm-born children. We hypothesised that reduced gas exchange in preterm-born children could be measured with dissolved 129Xe whole lung spectroscopy. The ratio of red blood cells (RBC) to tissue/plasma (TP) signals (RBC/TP) was significantly elevated in the lungs of 34 preterm-born children compared with 16 term-born children. This trend was unexpected and we hypothesise that in preterm-born children a reduced number of alveolar septa due to birth at an early stage of lung development can lead to decreased TP signal and thus increased RBC/TP ratio.

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