MRI of hyperpolarized 129Xe has been shown to be a robust, non-invasive biomarker to assess pulmonary disease pathophysiology. Static spin-density maps (ventilation images) are commonly analyzed using the ventilation defect percentage (VDP) to quantify the degree of airway obstruction in diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. However, VDP reduces the intrinsic 3D-spatial richness of ventilation images to a global measure, suppressing underlying spatial correlations. In this work, a gray-level run-length matrix (GLRLM) analysis is assessed as an adjunct to VDP analysis for quantifying obstruction in Cystic Fibrosis (CF) lung disease, relative to a healthy control cohort.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords