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Abstract #1174

Age and lung volume dependence of dissolved xenon-129 imaging parameters

Guilhem J. Collier1, Ho-Fung Chan1, Neil J. Stewart1, Graham Norquay1, Laurie J. Smith1, Madhwesha Rao1, Helen Marshall1, Rolf F. Schulte2, and Jim M. Wild1
1POLARIS, University of Sheffield, Sheffield, United Kingdom, 2GE Healthcare, Munich, Germany


This work investigates the correlation between age and pulmonary gas transfer measurements assessed with dissolved xenon-129 MRI in 26 healthy volunteers with an age range of 23 to 68yrs. Dependence on lung inflation is also investigated by performing imaging at total lung capacity. Results show significant negative correlations of xenon tissue uptake and blood transfer and suggest that an age-correction should be performed when reporting results. Imaging at total lung capacity also confirms a significant decrease in xenon gas transfer when compared to imaging during standard inspiratory breath-hold.

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