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Abstract #1175

Dynamic Free-Breathing Ventilation and Gas Exchange with Hyperpolarized Xenon-129

Faraz Amzajerdian1, Hooman Hamedani1, Ryan Baron1, Yi Xin1, Tahmina Achekzai1, Luis Loza1, Mostafa Ismail1, Ian Duncan1, Stephen Kadlecek1, Kai Ruppert1, and Rahim Rizi1
1University of Pennsylvania, Philadelphia, PA, United States


Hyperpolarized xenon-129 (HXe) imaging is capable of quantifying lung function through measurements of ventilation and gas exchange. However, traditional HXe approaches rely on long breath-holds for imaging, which may not be representative of steady-state behavior and are limited by the volume of gas that can be delivered. In this work, we imaged gas- and dissolved-phase xenon continuously over approximately 50 breaths and retrospectively binned the images, generating dynamic maps encompassing the entire respiratory cycle.

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